LASSBio-881: an N-acylhydrazone transient receptor potential vanilloid subfamily type 1 antagonist orally effective against the hypernociception induced by capsaicin or partial sciatic ligation

BACKGROUND AND PURPOSE: Compound LASSBio-881 is an orally effective antinociceptive that binds to cannabinoid receptors and is active mainly on the neurogenic component of pain models. We investigated whether transient receptor potential vanilloid subfamily type 1 (TRPV1) channels are involved in th...

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Detalhes bibliográficos
Main Authors: Tributino, JLM, Santos, MLH, Mesquita, CM, Lima, CKF, Silva, LL, Maia, RC, Duarte, CD, Barreiro, EJ, Fraga, CAM, Castro, NG, Miranda, ALP, Guimaraes, MZP
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925494/
https://ncbi.nlm.nih.gov/pubmed/20401963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00672.x
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