Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non-small cell lung cancer

Smoking is the most important known risk factor for the development of lung cancer. Tobacco exposure results in chronic inflammation, tissue injury and repair. A recent hypothesis argues for a stem/progenitor cell involved in airway epithelial repair that may be a tumor-initiating cell in lung cance...

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Autores principales: Ooi, Aik T., Mah, Vei, Nickerson, Derek W., Gilbert, Jennifer L., Ha, Vi Luan, Hegab, Ahmed E., Horvath, Steve, Alavi, Mohammad, Maresh, Erin L., Chia, David, Gower, Adam C., Lenburg, Marc E., Spira, Avrum, Solis, Luisa M., Wistuba, Ignacio I., Walser, Tonya C., Wallace, William D., Dubinett, Steven M., Goodglick, Lee, Gomperts, Brigitte N.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924777/
https://ncbi.nlm.nih.gov/pubmed/20710044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0455
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