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Enantioselective Synthesis of Axially Chiral Biaryls by the Pd-Catalyzed Suzuki-Miyaura Reaction: Substrate Scope and Quantum Mechanical Investigations

[Image: see text] We report efficient syntheses of axially chiral biaryl amides in yields ranging from 80–92%, and with enantioselectivity in the range 88–94% ee employing an asymmetric Suzuki-Miyaura process with Pd(OAc)(2) and KenPhos as ligand. These studies demonstrate that electron-rich and ele...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Shen, Xiaoqiang, Jones, Gavin O., Watson, Donald A., Bhayana, Brijesh, Buchwald, Stephen L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924746/
https://ncbi.nlm.nih.gov/pubmed/20698695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja104297g
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