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Enantioselective Synthesis of Axially Chiral Biaryls by the Pd-Catalyzed Suzuki-Miyaura Reaction: Substrate Scope and Quantum Mechanical Investigations
[Image: see text] We report efficient syntheses of axially chiral biaryl amides in yields ranging from 80–92%, and with enantioselectivity in the range 88–94% ee employing an asymmetric Suzuki-Miyaura process with Pd(OAc)(2) and KenPhos as ligand. These studies demonstrate that electron-rich and ele...
Wedi'i Gadw mewn:
| Prif Awduron: | , , , , |
|---|---|
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2010
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2924746/ https://ncbi.nlm.nih.gov/pubmed/20698695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja104297g |
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