Epicardial perivascular adipose-derived leptin exacerbates coronary endothelial dysfunction in metabolic syndrome via a PKC-β pathway

OBJECTIVE: Factors released by perivascular adipose tissue (PVAT) disrupt coronary endothelial function via phosphorylation of eNOS by PKC-β. However, our understanding of how PVAT potentially contributes to coronary disease as a complication of obesity/metabolic syndrome (MetS) remains limited. The...

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Bibliographic Details
Main Authors: Payne, Gregory A., Borbouse, Léna, Kumar, Sajel, Neeb, Zachary, Alloosh, Mouhamad, Sturek, Michael, Tune, Johnathan D.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924445/
https://ncbi.nlm.nih.gov/pubmed/20576943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.210070
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