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Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle

Src-family kinases (SFKs) play a pivotal role in growth factor signaling, mitosis, cell motility and invasiveness. In their basal state, SFKs maintain a closed autoinhibited conformation where the Src homology 2 domain interacts with an inhibitory phosphotyrosine in the C-terminus. Activation involv...

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Hlavní autoři: Kaimachnikov, Nikolai P., Kholodenko, Boris N.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924194/
https://ncbi.nlm.nih.gov/pubmed/19627364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2009.07117.x
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