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Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle
Src-family kinases (SFKs) play a pivotal role in growth factor signaling, mitosis, cell motility and invasiveness. In their basal state, SFKs maintain a closed autoinhibited conformation where the Src homology 2 domain interacts with an inhibitory phosphotyrosine in the C-terminus. Activation involv...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2924194/ https://ncbi.nlm.nih.gov/pubmed/19627364 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2009.07117.x |
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