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Smad3 Regulates Rho Signaling via NET1 in the Transforming Growth Factor-β-induced Epithelial-Mesenchymal Transition of Human Retinal Pigment Epithelial Cells

We previously demonstrated that RhoA-dependent signaling regulates transforming growth factor-β1 (TGF-β1)-induced cytoskeletal reorganization in the human retinal pigment epithelial cell line ARPE-19. Smad pathways have also been shown to mediate TGF-β1 activity. Here, we examined what regulates Rho...

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Autores principales: Lee, Jungeun, Moon, Hyun-Jeong, Lee, Jong-Min, Joo, Choun-Ki
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924101/
https://ncbi.nlm.nih.gov/pubmed/20547485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.073155
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