Restoration of Dlk1 and Rtl1 Is Necessary but Insufficient to Rescue Lethality in Intergenic Differentially Methylated Region (IG-DMR)-deficient Mice

In the Dlk1-Dio3 imprinted domain, an intergenic differentially methylated region (IG-DMR) regulates the parental allele-specific expression of imprinted genes. The maternally inherited deletion of IG-DMR (IG-DMR((−/+))) results in perinatal lethality because of the overexpression of paternally expr...

Full description

Saved in:
Bibliographic Details
Main Authors: Takahashi, Nozomi, Kobayashi, Ryota, Kono, Tomohiro
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924016/
https://ncbi.nlm.nih.gov/pubmed/20511218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.075325
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items