Assembly of fibrillin microfibrils governs extracellular deposition of latent TGFβ

Control of the bioavailability of the growth factor TGFβ is essential for tissue formation and homeostasis, yet precisely how latent TGFβ is incorporated into the extracellular matrix is unknown. Here, we show that deposition of a large latent TGFβ complex (LLC), which contains latent TGFβ-binding p...

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Détails bibliographiques
Auteurs principaux: Massam-Wu, Teresa, Chiu, Maybo, Choudhury, Rawshan, Chaudhry, Shazia S., Baldwin, Andrew K., McGovern, Amanda, Baldock, Clair, Shuttleworth, C. Adrian, Kielty, Cay M.
Format: Artigo
Langue:Inglês
Publié: Company of Biologists 2010
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923573/
https://ncbi.nlm.nih.gov/pubmed/20699357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.073437
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