Dendritic Cell-Targeted Pancreatic β-Cell Antigen Leads to Conversion of Self-Reactive CD4(+) T Cells Into Regulatory T Cells and Promotes Immunotolerance in NOD Mice

Studies employing T cell receptor transgenic T cells have convincingly shown that selective delivery of non-self model antigens to DEC-205(+) dendritic cells (DCs) in the steady-state can induce Foxp3-expressing CD4(+)CD25(+) regulatory T (Treg) cells from conventional CD4(+)CD25(-)Foxp3(-) T cells....

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Autors principals: Petzold, Cathleen, Riewaldt, Julia, Koenig, Tina, Schallenberg, Sonja, Kretschmer, Karsten
Format: Artigo
Idioma:Inglês
Publicat: SBDR - Society for Biomedical Diabetes Research 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923380/
https://ncbi.nlm.nih.gov/pubmed/20703438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1900/RDS.2010.7.47
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