RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis

The small GTPase RhoA and its downstream effectors, ROCK1 and ROCK2, regulate a number of cellular processes, including cell motility, proliferation, survival, and permeability. Pharmacological inhibitors of the Rho pathway reportedly block angiogenesis; however, the molecular details of this inhibi...

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Detalhes bibliográficos
Main Authors: Bryan, Brad A., Dennstedt, Emily, Mitchell, Dianne C., Walshe, Tony E., Noma, Kensuke, Loureiro, Robyn, Saint-Geniez, Magali, Campaigniac, Jean-Paul, Liao, James K., D'Amore, Patricia A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2010
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923346/
https://ncbi.nlm.nih.gov/pubmed/20400538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-145102
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