Mitochondrial Dysfunction Induced by Different Organochalchogens Is Mediated by Thiol Oxidation and Is Not Dependent of the Classical Mitochondrial Permeability Transition Pore Opening

Ebselen (Ebs) and diphenyl diselenide [(PhSe)(2)] readily oxidize thiol groups. Here we studied mitochondrial swelling changes in mitochondrial potential (Δψm), NAD(P)H oxidation, reactive oxygen species production, protein aggregate formation, and oxygen consumption as ending points of their in vit...

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Detalhes bibliográficos
Main Authors: Puntel, Robson L., Roos, Daniel H., Folmer, Vanderlei, Nogueira, Cristina W., Galina, Antonio, Aschner, Michael, Rocha, João B. T.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Molecular Toxicology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923288/
https://ncbi.nlm.nih.gov/pubmed/20573786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfq185
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