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The Impact of mRNA Structure on Guide RNA Targeting in Kinetoplastid RNA Editing

Mitochondrial mRNA editing in Trypanosoma brucei requires the specific interaction of a guide RNA with its cognate mRNA. Hundreds of gRNAs are involved in the editing process, each needing to target their specific editing domain within the target message. We hypothesized that the structure surroundi...

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Detalhes bibliográficos
Main Authors: Reifur, Larissa, Yu, Laura E., Cruz-Reyes, Jorge, vanHartesvelt, Michelle, Koslowsky, Donna J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923197/
https://ncbi.nlm.nih.gov/pubmed/20808932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012235
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