Generation of human induced pluripotent stem cells by simple transient transfection of plasmid DNA encoding reprogramming factors

BACKGROUND: The use of lentiviruses to reprogram human somatic cells into induced pluripotent stem (iPS) cells could limit their therapeutic usefulness due to the integration of viral DNA sequences into the genome of the recipient cell. Recent work has demonstrated that human iPS cells can be genera...

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Bibliographic Details
Main Authors: Si-Tayeb, Karim, Noto, Fallon K, Sepac, Ana, Sedlic, Filip, Bosnjak, Zeljko J, Lough, John W, Duncan, Stephen A
Format: Artigo
Language:Inglês
Published: BioMed Central 2010
Subjects:
Methodology Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923111/
https://ncbi.nlm.nih.gov/pubmed/20682060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-213X-10-81
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