Sirtuin 1 regulation of developmental genes during differentiation of stem cells

The longevity-promoting NAD(+)–dependent class III histone deacetylase Sirtuin 1 (SIRT1) is involved in stem cell function by controlling cell fate decision and/or by regulating the p53-dependent expression of NANOG. We show that SIRT1 is down-regulated precisely during human embryonic stem cell dif...

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Autors principals: Calvanese, Vincenzo, Lara, Ester, Suárez-Álvarez, Beatriz, Abu Dawud, Raed, Vázquez-Chantada, Mercedes, Martínez-Chantar, Maria Luz, Embade, Nieves, López-Nieva, Pilar, Horrillo, Angelica, Hmadcha, Abdelkrim, Soria, Bernat, Piazzolla, Daniela, Herranz, Daniel, Serrano, Manuel, Mato, Jose María, Andrews, Peter W., López-Larrea, Carlos, Esteller, Manel, Fraga, Mario F.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922228/
https://ncbi.nlm.nih.gov/pubmed/20631301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1001399107
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