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Evidence that fold-change, and not absolute level, of β-catenin dictates Wnt signaling
In the canonical Wnt pathway, binding of the Wnt ligand to its transmembrane receptors leads to an inhibition of the degradation of β-catenin; as a result, β-catenin accumulates to a point where it activates target genes. Using mathematical modeling and experiments in mammalian cells, we examined th...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2921914/ https://ncbi.nlm.nih.gov/pubmed/20005849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.11.017 |
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