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Evidence that fold-change, and not absolute level, of β-catenin dictates Wnt signaling

In the canonical Wnt pathway, binding of the Wnt ligand to its transmembrane receptors leads to an inhibition of the degradation of β-catenin; as a result, β-catenin accumulates to a point where it activates target genes. Using mathematical modeling and experiments in mammalian cells, we examined th...

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Détails bibliographiques
Auteurs principaux: Goentoro, Lea, Kirschner, Marc W.
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921914/
https://ncbi.nlm.nih.gov/pubmed/20005849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.11.017
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