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Spatial regulation of Golgi phosphatidylinositol-4-phosphate is required for enzyme localization and glycosylation fidelity

The enrichment of phosphatidylinositol-4-phosphate (PI(4)P) at the trans-Golgi-network (TGN) is instrumental for proper protein and lipid sorting, yet how the restricted distribution of PI(4)P is achieved remains unknown. Here we show that lipid phosphatase SAC1 is crucial for the spatial regulation...

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Detalhes bibliográficos
Main Authors: Cheong, Fei Ying, Sharma, Vandana, Blagoveshchenskaya, Anastasia, Oorschot, Viola M J, Brankatschk, Ben, Klumperman, Judith, Freeze, Hudson H, Mayinger, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921771/
https://ncbi.nlm.nih.gov/pubmed/20573065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0854.2010.01092.x
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