Polymorphic Variants of LIGHT (TNF Superfamily-14) Alter Receptor Avidity and Bioavailability

The TNF superfamily member, LIGHT (TNFSF14) is a key cytokine that activates T cells and dendritic cells, and is implicated as a mediator of inflammatory, metabolic and malignant diseases. LIGHT engages the Lymphotoxin-β receptor (LTβR) and herpesvirus entry mediator (HVEM, TNFRSF14), but is competi...

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Autori principali: Cheung, Timothy C., Coppieters, Ken, Sanjo, Hideki, Oborne, Lisa M., Norris, Paula S., Coddington, Amy, Granger, Steven W., Elewaut, Dirk, Ware, Carl F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921593/
https://ncbi.nlm.nih.gov/pubmed/20592286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001159
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