Preclinical Pharmacokinetic Analysis of NOV-002, a Glutathione Disulfide Mimetic

NOV-002 is a glutathione disulfide (GSSG) mimetic that is in Phase III clinical trials for the treatment of advanced non-small cell lung cancer and other oncology indications. GSSG is reduced by glutathione reductase (GR) to form glutathione (GSH), thereby maintaining redox homeostasis. The purpose...

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Bibliographic Details
Main Authors:	Uys, Joachim D., Manevich, Yefim, DeVane, Lindsay C., He, Lin, Garret, Tracy E., Pazoles, Christopher J., Tew, Kenneth D., Townsend, Danyelle M.
Format:	Artigo
Language:	Inglês
Published:	2010
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2921589/ https://ncbi.nlm.nih.gov/pubmed/20359856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopha.2010.01.003
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Preclinical Pharmacokinetic Analysis of NOV-002, a Glutathione Disulfide Mimetic

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