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Preclinical Pharmacokinetic Analysis of NOV-002, a Glutathione Disulfide Mimetic
NOV-002 is a glutathione disulfide (GSSG) mimetic that is in Phase III clinical trials for the treatment of advanced non-small cell lung cancer and other oncology indications. GSSG is reduced by glutathione reductase (GR) to form glutathione (GSH), thereby maintaining redox homeostasis. The purpose...
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| Glavni autori: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2921589/ https://ncbi.nlm.nih.gov/pubmed/20359856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopha.2010.01.003 |
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