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Modeling Smooth Muscle Myosin's Two Heads: Long-Lived Enzymatic Roles and Phosphorylation-Dependent Equilibria

Smooth muscle myosin has two heads, each capable of interacting with actin to generate force and/or motion as it hydrolyzes ATP. These heads are inhibited when their associated regulatory light chain is unphosphorylated (0P), becoming active and hydrolyzing ATP maximally when phosphorylated (2P). In...

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Autori principali: Walcott, Sam, Warshaw, David M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920627/
https://ncbi.nlm.nih.gov/pubmed/20712996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.06.018
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