Hypoxia induces a phenotypic switch of fibroblasts to myofibroblasts through a MMP-2/TIMP mediated pathway: Implications for venous neointimal hyperplasia in hemodialysis access

PURPOSE: Hemodialysis grafts fail because of venous neointimal hyperplasia formation caused by adventitial fibroblasts which have become myofibroblasts (α-smooth muscle actin positive cells) and migrate to the neointima. There is increased expression of hypoxia inducible factor-1 alpha (HIF-1α in ve...

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Main Authors: Misra, Sanjay, Fu, Alex A., Misra, Khamal D., Shergill, Uday M., Leof, Edward B, Mukhopadhyay, Debabrata
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920497/
https://ncbi.nlm.nih.gov/pubmed/20434368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jvir.2010.02.030
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