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The C-terminus of Utp4, mutated in childhood cirrhosis, is essential for ribosome biogenesis

The small subunit (SSU) processome is a large ribonucleoprotein that is required for maturation of the 18S rRNA of the ribosome. Recently, a missense mutation in the C-terminus of an SSU processome protein, Utp4/Cirhin, was reported to cause North American Indian childhood cirrhosis (NAIC). In this...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Freed, Emily F., Baserga, Susan J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919705/
https://ncbi.nlm.nih.gov/pubmed/20385600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq185
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