Role of Protein Kinase Cζ in Thrombin-induced RhoA Activation and Interendothelial Gap Formation of Human Dermal Microvessel Endothelial Cell Monolayers

We studied the potential involvement of the Ca(2+)-independent atypical protein kinase C isoform PKCζ in mediating the thrombin-induced increase in endothelial permeability. Studies were done using human dermal microvessel endothelial cells (HMEC), which we showed constitutively expressed PKCζ. We q...

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Detalhes bibliográficos
Main Authors: Minshall, Richard D., Vandenbroucke, Emily E., Holinstat, Michael, Place, Aaron T., Tiruppathi, Chinnaswamy, Vogel, Stephen M., van NieuwAmerongen, Geerten P., Mehta, Dolly, Malik, Asrar B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919649/
https://ncbi.nlm.nih.gov/pubmed/20417648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mvr.2010.04.007
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