Longitudinal Brain Corticotropin Releasing Factor and Somatostatin in a Transgenic Mouse (TG2576) Model of Alzheimer's Disease

Neuropeptides corticotropin releasing factor (CRF) and somatostatin (SRIF) are substantially decreased in cortical regions of Alzheimer's disease (AD) post-mortem brain tissue. The accumulation of amyloid-β (Aβ) in AD brain has been postulated to be neurotoxic. Using male Tg2576 mice transgenic...

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Main Authors: Horgan, Jennifer, Miguel-Hidalgo, Jose Javier, Thrasher, Martha, Bissette, Garth
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919580/
https://ncbi.nlm.nih.gov/pubmed/17917156
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