Immunization with Cocktail of HIV-Derived Peptides in Montanide ISA-51 Is Immunogenic, but Causes Sterile Abscesses and Unacceptable Reactogenicity

BACKGROUND: A peptide vaccine was produced containing B and T cell epitopes from the V3 and C4 Envelope domains of 4 subtype B HIV-1 isolates (MN, RF, CanO, & Ev91). The peptide mixture was formulated as an emulsion in incomplete Freund's adjuvant (IFA). METHODS: Low-risk, healthy adult sub...

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Detalhes bibliográficos
Main Authors: Graham, Barney S., McElrath, M. Juliana, Keefer, Michael C., Rybczyk, Kyle, Berger, David, Weinhold, Kent J., Ottinger, Janet, Ferarri, Guido, Montefiori, David C., Stablein, Don, Smith, Carol, Ginsberg, Richard, Eldridge, John, Duerr, Ann, Fast, Pat, Haynes, Barton F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919382/
https://ncbi.nlm.nih.gov/pubmed/20706632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011995
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