Immunization with Cocktail of HIV-Derived Peptides in Montanide ISA-51 Is Immunogenic, but Causes Sterile Abscesses and Unacceptable Reactogenicity

BACKGROUND: A peptide vaccine was produced containing B and T cell epitopes from the V3 and C4 Envelope domains of 4 subtype B HIV-1 isolates (MN, RF, CanO, & Ev91). The peptide mixture was formulated as an emulsion in incomplete Freund's adjuvant (IFA). METHODS: Low-risk, healthy adult sub...

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Detaylı Bibliyografya
Asıl Yazarlar: Graham, Barney S., McElrath, M. Juliana, Keefer, Michael C., Rybczyk, Kyle, Berger, David, Weinhold, Kent J., Ottinger, Janet, Ferarri, Guido, Montefiori, David C., Stablein, Don, Smith, Carol, Ginsberg, Richard, Eldridge, John, Duerr, Ann, Fast, Pat, Haynes, Barton F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2010
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919382/
https://ncbi.nlm.nih.gov/pubmed/20706632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011995
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