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Regulation of G-protein coupled receptor traffic by an evolutionary conserved hydrophobic signal

Plasma membrane (PM) expression of G-protein coupled receptors (GPCRs) is required for activation by extracellular ligands; however mechanisms that regulate PM expression of GPCRs are poorly understood. For some GPCRs, such as alpha2c-adrenergic receptors (α(2c)-ARs), heterologous expression in non-...

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Detalhes bibliográficos
Main Authors: Angelotti, Tim, Daunt, David, Shcherbakova, Olga G., Kobilka, Brian, Hurt, Carl M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919199/
https://ncbi.nlm.nih.gov/pubmed/20059747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0854.2010.01033.x
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