MULTIPLE PROTEIN KINASE PATHWAYS MEDIATE AMPLIFIED IL-6 RELEASE BY HUMAN LUNG FIBROBLASTS CO-EXPOSED TO NICKEL AND TLR-2 AGONIST, MALP-2

Microbial stimuli and atmospheric particulate matter (PM) interact to amplify the release of inflammatory and immune-modulating cytokines. The basis of this interaction, however, is not known. Cultured human lung fibroblasts (HLF) were used to determine whether various protein kinase pathways were i...

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Hauptverfasser: Gao, Fei, Brant, Kelly A., Ward, Rachel M., Cattley, Richard T., Barchowsky, Aaron, Fabisiak, James P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919161/
https://ncbi.nlm.nih.gov/pubmed/20600219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2010.06.007
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