Gadd45b Mediates Fas-induced Apoptosis by Enhancing the Interaction between p38 and Retinoblastoma Tumor Suppressor

Gadd45b has been known as a positive mediator of apoptosis induced by certain cytokines and oncogenes. Here, we identified Gadd45b as an effector of Fas-induced apoptosis and found that p38-mediated Rb hyperphosphorylation is one of the mechanisms of Fas-induced apoptosis in murine hepatocyte AML12...

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Hlavní autoři: Cho, Hee Jun, Park, Sun-Mi, Hwang, Eun Mi, Baek, Kyoung Eun, Kim, In-Kyu, Nam, In-Koo, Im, Min-Ju, Park, Seung-Ho, Bae, Seran, Park, Jae-Yong, Yoo, Jiyun
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919113/
https://ncbi.nlm.nih.gov/pubmed/20558744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.091413
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