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Increased Mutation Frequency in Redox-Impaired Escherichia coli Due to RelA- and RpoS-Mediated Repression of DNA Repair

Balancing of reducing equivalents is a fundamental issue in bacterial metabolism and metabolic engineering. Mutations in the key metabolic genes ldhA and pflB of Escherichia coli are known to stall anaerobic growth and fermentation due to a buildup of intracellular NADH. We observed that the rate of...

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Detalhes bibliográficos
Main Authors: Singh, Amarjeet, Karimpour-Fard, Anis, Gill, Ryan T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918982/
https://ncbi.nlm.nih.gov/pubmed/20581184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00583-10
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