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Flexibility of a biotinylated ligand in artificial metalloenzymes based on streptavidin—an insight from molecular dynamics simulations with classical and ab initio force fields

In the field of enzymatic catalysis, creating activity from a non catalytic scaffold is a daunting task. Introduction of a catalytically active moiety within a protein scaffold offers an attractive means for the creation of artificial metalloenzymes. With this goal in mind, introduction of a biotiny...

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Bibliografski detalji
Glavni autori: Panek, Jarosław J., Ward, Thomas R., Jezierska-Mazzarello, Aneta, Novič, Marjana
Format: Artigo
Jezik:Inglês
Izdano: Springer Netherlands 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918797/
https://ncbi.nlm.nih.gov/pubmed/20526651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-010-9369-x
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