Neuronal JNK pathway activation by IL-1 is mediated through IL1RAPL1, a protein required for development of cognitive functions

Interleukin-1-Receptor Accessory Protein Like 1 (IL1RAPL1) gene mutations are associated to cognitive impairment ranging from non-syndromic X-linked mental retardation to autism. Functionally IL1RAPL1 belongs to a novel family of Toll/IL-1 Receptors, but its ligand is unknown. In a recent study, we...

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Main Authors: Pavlowsky, Alice, Zanchi, Alice, Pallotto, Marta, Giustetto, Maurizio, Chelly, Jamel, Sala, Carlo, Billuart, Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918768/
https://ncbi.nlm.nih.gov/pubmed/20714405
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