Synthesis of Aryl-Heteroaryl Ureas (AHUs) Based on 4-Aminoquinoline and Their Evaluation Against the Insulin-Like Growth Factor Receptor (IGF-1R)

The insulin-like growth factor receptor (IGF-1R) is a receptor tyrosine kinase (RTK) involved in all stages of the development and propagation of breast and other cancers. The inhibition of IGF-1R by small molecules remains a promising strategy to treat cancer. Herein, we explore SAR around previous...

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Autori principali: Engen, William, O’Brien, Terrence E., Kelly, Brendan, Do, Jacinda, Rillera, Liezel, Stapleton, Lance, Youngren, Jack F., Anderson, Marc O.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918655/
https://ncbi.nlm.nih.gov/pubmed/20643554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.06.071
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