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A La protein requirement for efficient pre-tRNA folding

The La protein protects the 3′ ends of many nascent small RNAs from exonucleases. Here we report that La is required for efficient folding of certain pre-tRNAs. A mutation in pre-tRNA(Arg)(CCG) causes yeast cells to be cold-sensitive and to require the La protein Lhp1p for efficient growth. When the...

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Detalhes bibliográficos
Main Authors: Chakshusmathi, Ghadiyaram, Kim, Sang Do, Rubinson, Douglas A., Wolin, Sandra L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC291820/
https://ncbi.nlm.nih.gov/pubmed/14657028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg625
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