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Translational read-through of a nonsense mutation in ATP7A impacts treatment outcome in Menkes disease

Protein translation ends when a stop codon in a gene’s messenger RNA transcript enters the ribosomal A site. Mutations that create premature stop codons (nonsense mutations) typically cause premature translation termination. An alternative outcome, read-through translation (or nonsense suppression),...

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書誌詳細
主要な著者: Kaler, Stephen G., Tang, Jingrong, Donsante, Anthony, Kaneski, Christine
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917729/
https://ncbi.nlm.nih.gov/pubmed/19194885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.21576
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