Sonic Hedgehog Induces Angiogenesis via Rho Kinase-dependent Signaling in Endothelial Cells

The morphogen Sonic Hedgehog (Shh) promotes neovascularization in adults by inducing pro-angiogenic cytokine expression in fibroblasts; however, the direct effects of Shh on endothelial cell (EC) function during angiogenesis are unknown. Our findings indicate that Shh promotes capillary morphogenesi...

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Main Authors: Renault, Marie-Ange, Roncalli, Jérôme, Tongers, Jörn, Thorne, Tina, Klyachko, Ekaterina, Misener, Sol, Volpert, Olga V., Mehta, Shanu, Burg, Aaron, Luedemann, Corinne, Qin, Gangjian, Kishore, Raj, Losordo, Douglas W.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917529/
https://ncbi.nlm.nih.gov/pubmed/20478312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.05.003
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