Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction

RATIONALE: Cardiac fibroblasts are key effector cells in the pathogenesis of cardiac fibrosis. Transforming Growth Factor (TGF)-βSmad3 signaling is activated in the border zone of healing infarcts and induces fibrotic remodeling of the infarcted ventricle contributing to the development of diastolic...

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Main Authors: Dobaczewski, Marcin, Bujak, Marcin, Li, Na, Gonzalez-Quesada, Carlos, Mendoza, Leonardo H, Wang, Xiao-Fan, Frangogiannis, Nikolaos G
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917472/
https://ncbi.nlm.nih.gov/pubmed/20522804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.216101
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