The estrogen receptor influences microtubule-associated protein tau (MAPT) expression and the selective estrogen receptor inhibitor fulvestrant downregulates MAPT and increases the sensitivity to taxane in breast cancer cells

INTRODUCTION: Microtubule-associated protein tau (MAPT) inhibits the function of taxanes and high expression of MAPT decreases the sensitivity to taxanes. The relationship between estrogen receptor (ER) and MAPT in breast cancer is unclear. In this study, we examined the correlation of MAPT expressi...

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Main Authors: Ikeda, Hirokuni, Taira, Naruto, Hara, Fumikata, Fujita, Takeo, Yamamoto, Hiromasa, Soh, Junichi, Toyooka, Shinichi, Nogami, Tomohiro, Shien, Tadahiko, Doihara, Hiroyoshi, Miyoshi, Shinichiro
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917038/
https://ncbi.nlm.nih.gov/pubmed/20579400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2598
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