Breast cancer-specific mutations in CK1ε inhibit Wnt/β-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration

INTRODUCTION: Breast cancer is one of the most common types of cancer in women. One of the genes that were found mutated in breast cancer is casein kinase 1 epsilon (CK1ε). Because CK1ε is a crucial regulator of the Wnt signaling cascades, we determined how these CK1ε mutations interfere with the Wn...

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Detalhes bibliográficos
Main Authors: Foldynová-Trantírková, Silvie, Sekyrová, Petra, Tmejová, Kateřina, Brumovská, Eva, Bernatík, Ondřej, Blankenfeldt, Wulf, Krejčí, Pavel, Kozubík, Alois, Doležal, Tomáš, Trantírek, Lukáš, Bryja, Vítězslav
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917022/
https://ncbi.nlm.nih.gov/pubmed/20507565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2581
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