Cyclophosphamide- metabolizing enzyme polymorphisms and survival outcomes after adjuvant chemotherapy for node-positive breast cancer: a retrospective cohort study

INTRODUCTION: Cyclophosphamide-based adjuvant chemotherapy is a mainstay of treatment for women with node-positive breast cancer, but is not universally effective in preventing recurrence. Pharmacogenetic variability in drug metabolism is one possible mechanism of treatment failure. We hypothesize t...

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Main Authors: Gor, Priya P, Su, H Irene, Gray, Robert J, Gimotty, Phyllis A, Horn, Michelle, Aplenc, Richard, Vaughan, William P, Tallman, Martin S, Rebbeck, Timothy R, DeMichele, Angela
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917014/
https://ncbi.nlm.nih.gov/pubmed/20459744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2570
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