Maternal high-fat diet interacts with embryonic Cited2 genotype to reduce Pitx2c expression and enhance penetrance of left–right patterning defects

Deficiency of the transcription factor Cited2 in mice results in cardiac malformation, adrenal agenesis, neural tube, placental defects and partially penetrant cardiopulmonary laterality defects resulting from an abnormal Nodal->Pitx2c pathway. Here we show that a maternal high-fat diet more than...

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Bibliografiske detaljer
Main Authors: Bentham, Jamie, Michell, Anna C., Lockstone, Helen, Andrew, Daniel, Schneider, Jürgen E., Brown, Nigel A., Bhattacharya, Shoumo
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2010
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916708/
https://ncbi.nlm.nih.gov/pubmed/20566713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq251
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