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Multiple Nucleotide Substitutions in the Neisseria meningitidis Serogroup C ctrA Gene Cause False-Negative Detection by Real-Time PCR

Two strains of Neisseria meningitidis serogroup C with disparate sequences of ctrA were isolated. The nucleotide substitutions did not alter the corresponding protein sequences, but they impeded the detection of these meningococcal isolates by real-time PCR.

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Bibliographic Details
Main Authors: Cavrini, Francesca, Liguori, Giovanna, Andreoli, Arianna, Sambri, Vittorio
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916631/
https://ncbi.nlm.nih.gov/pubmed/20519469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.00103-10
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