Role of the Membrane Localization Domain of the Pseudomonas aeruginosa Effector Protein ExoU in Cytotoxicity

ExoU is a potent effector protein that causes rapid host cell death upon injection by the type III secretion system of Pseudomonas aeruginosa. The N-terminal half of ExoU contains a patatin-like phospholipase A(2) (PLA(2)) domain that requires the host cell cofactor superoxide dismutase 1 (SOD1) for...

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Main Authors: Veesenmeyer, Jeff L., Howell, Heather, Halavaty, Andrei S., Ahrens, Sebastian, Anderson, Wayne F., Hauser, Alan R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Molecular Pathogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916264/
https://ncbi.nlm.nih.gov/pubmed/20479080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00223-10
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