Structural and Kinetic Analysis of Free Methionine-R-sulfoxide Reductase from Staphylococcus aureus: CONFORMATIONAL CHANGES DURING CATALYSIS AND IMPLICATIONS FOR THE CATALYTIC AND INHIBITORY MECHANISMS

Free methionine-R-sulfoxide reductase (fRMsr) reduces free methionine R-sulfoxide back to methionine, but its catalytic mechanism is poorly understood. Here, we have determined the crystal structures of the reduced, substrate-bound, and oxidized forms of fRMsr from Staphylococcus aureus. Our structu...

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Autores principales: Bong, Seoung Min, Kwak, Geun-Hee, Moon, Jin Ho, Lee, Ki Seog, Kim, Hong Seok, Kim, Hwa-Young, Chi, Young Min
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915740/
https://ncbi.nlm.nih.gov/pubmed/20504774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.103119
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