Plasminogen Activator Inhibitor-1 Is a Transcriptional Target of the Canonical Pathway of Wnt/β-Catenin Signaling

Plasminogen activator inhibitor-1 (PAI-1) is a multifunctional glycoprotein that plays a critical role in the pathogenesis of chronic kidney and cardiovascular diseases. Although transforming growth factor (TGF)-β1 is a known inducer of PAI-1, how it controls PAI-1 expression remains enigmatic. Here...

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Bibliografiske detaljer
Main Authors: He, Weichun, Tan, Ruoyun, Dai, Chunsun, Li, Yingjian, Wang, Dan, Hao, Sha, Kahn, Michael, Liu, Youhua
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915703/
https://ncbi.nlm.nih.gov/pubmed/20519507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.091256
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