Inhibition of Golgi Apparatus Glycosylation Causes Endoplasmic Reticulum Stress and Decreased Protein Synthesis

Nucleotide sugar transporters of the Golgi apparatus play an essential role in the glycosylation of proteins, lipids, and proteoglycans. Down-regulation of expression of the transporters for CMP-sialic acid, GDP-fucose, or both unexpectedly resulted in accumulation of glycoconjugates in the Golgi ap...

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Bibliographic Details
Main Authors: Xu, Yu-Xin, Liu, Li, Caffaro, Carolina E., Hirschberg, Carlos B.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915696/
https://ncbi.nlm.nih.gov/pubmed/20529871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.134544
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