Mechanistic Insights into the Events That Lead to Synergistic Induction of Interleukin 6 Transcription upon Activation of the Aryl Hydrocarbon Receptor and Inflammatory Signaling

The aryl hydrocarbon receptor (AHR) is the ligand-activated transcription factor responsible for mediating the toxicological effects of dioxin and xenobiotic metabolism. However, recent evidence has implicated the AHR in additional, nonmetabolic physiological processes, including immune regulation....

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Bibliographic Details
Main Authors: DiNatale, Brett C., Schroeder, Jennifer C., Francey, Lauren J., Kusnadi, Ann, Perdew, Gary H.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915674/
https://ncbi.nlm.nih.gov/pubmed/20511231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.118570
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