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Cys-141 glutathionylation of human p53: Studies using specific polyclonal antibodies in cancer samples and cell lines

Previously, we reported that human p53 is functionally inactivated by S-glutathionylation at Cys-141 during oxidative and DNA-damaging treatments. Here, we describe the presence of thiolated p53 and dynamic nature of this modification in human tissues using unique and specific polyclonal antibodies...

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Hlavní autoři: Yusuf, Mohd. A., Chuang, Trinette, Bhat, G. Jayarama, Srivenugopal, Kalkunte S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914855/
https://ncbi.nlm.nih.gov/pubmed/20600834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2010.06.020
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