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Scheduling of Radiation with Angiogenesis Inhibitors Anginex and Avastin Improves Therapeutic Outcome via Vessel Normalization

PURPOSE: To test whether a direct antiangiogenic peptide (anginex) and a vascular endothelial growth factor antibody (bevacizumab, Avastin) can transiently normalize vasculature within tumors to improve oxygen delivery, alleviate hypoxia, and increase the effect of radiation therapy. EXPERIMENTAL DE...

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Autors principals: Dings, Ruud P.M., Loren, Melissa, Heun, Hanke, McNiel, Elizabeth, Griffioen, Arjan W., Mayo, Kevin H., Griffin, Robert J.
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914684/
https://ncbi.nlm.nih.gov/pubmed/17545548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-06-2441
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