Effect of β(2)-adrenergic receptor polymorphism on response to longacting β(2) agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial

BACKGROUND: Combined long-acting β(2)-agonist and inhaled corticosteroid (LABA/ICS) therapy improves outcomes in many asthmatics. Some studies suggest that patients homozygous for arginine at the 16(th) amino-acid position of the β(2) adrenergic receptor (B16 Arg/Arg) benefit less than those with B1...

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Main Authors: Wechsler, Michael E., Kunselman, Susan J., Chinchilli, Vernon M, Bleecker, Eugene, Boushey, Homer A., Calhoun, William J., Ameredes, Bill T., Castro, Mario, Craig, Timothy J, Denlinger, Loren, Fahy, John V., Jarjour, Nizar, Kazani, Shamsah, Kim, Sophia, Kraft, Monica, Lazarus, Stephen C., Lemanske, Robert F, Markezich, Amy, Martin, Richard J., Permaul, Perdita, Peters, Stephen P, Ramsdell, Joe, Sorkness, Christine A., Sutherland, E Rand, Szefler, Stanley J, Walter, Michael J, Wasserman, Stephen, Israel, Elliot
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914569/
https://ncbi.nlm.nih.gov/pubmed/19932356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(09)61492-6
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