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Mucoadhesive Microdiscs Engineered for Ophthalmic Drug Delivery: Effect of Particle Geometry and Formulation on Preocular Residence Time

PURPOSE: To test the hypothesis that mucoadhesive microdiscs formulated in a rapidly dissolving tablet can increase preocular residence time. METHODS: Microparticles, smaller than 10 μm in diameter, were fabricated by emulsification with poly(lactic-co-glycolic acid) (PLG) as a core material and, in...

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Detalhes bibliográficos
Main Authors: Choy, Young Bin, Park, Jung-Hwan, McCarey, Bernard E., Edelhauser, Henry F., Prausnitz, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914553/
https://ncbi.nlm.nih.gov/pubmed/18689699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.08-2515
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