Single Nucleotide Polymorphisms in Monocyte Chemoattractant Protein-1 and Its Receptor Act Synergistically to Increase the Risk of Carotid Atherosclerosis

BACKGROUND: Monocyte chemoattractant protein 1 (MCP-1), acting in concert with its receptor chemokine receptor 2 (CCR2), promotes recruitment of macrophages into atherosclerotic plaque. We examined whether single nucleotide polymorphism (SNP) variants in the MCP-1 or CCR2 genes independently or in c...

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Detalhes bibliográficos
Main Authors: Nyquist, Paul A., Winkler, Cherie A., McKenzie, Louise M., Yanek, Lisa R., Becker, Lewis C., Becker, Diane M.
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2009
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914430/
https://ncbi.nlm.nih.gov/pubmed/19506371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000223437
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